Ontology highlight
ABSTRACT:
SUBMITTER: Ahmad S
PROVIDER: S-EPMC46053 | biostudies-other | 1993 Mar
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19930301 6
A cDNA encoding a nontransmembrane protein-tyrosine phosphatase (PTP; EC 3.1.3.48), termed PTP2C, was isolated from a human umbilical cord cDNA library. The enzyme contains a single phosphatase domain and two adjacent copies of the src homology 2 (SH2) domain at its amino terminus. A variant of PTP2C (PTP2Ci) which has four extra amino acid residues within the catalytic domain has been identified also. PTP2C is widely expressed in human tissues and is particularly abundant in heart, brain, and s ...[more]