Ontology highlight
ABSTRACT:
SUBMITTER: Tsai FL
PROVIDER: S-EPMC4614839 | biostudies-other | 2014
REPOSITORIES: biostudies-other
Tsai Feng-Ling FL Kai Mihoko M
Cell cycle (Georgetown, Tex.) 20140101 21
DNA damage activates the cell cycle checkpoint to regulate cell cycle progression. The checkpoint clamp (Rad9-Hus1-Rad1 complex) is recruited to damage sites, and is required for checkpoint activation. While functions of the checkpoint clamp in checkpoint activation have been well studied, its functions in DNA repair regulation remain elusive. Here we show that Rad9 is required for efficient homologous recombination (HR), and facilitates DNA-end resection. The role of Rad9 in homologous recombin ...[more]