Ontology highlight
ABSTRACT:
SUBMITTER: Kalfalah FM
PROVIDER: S-EPMC4614858 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Kalfalah Faiza M FM Berg Elke E Christensen Morten O MO Linka René M RM Dirks Wilhelm G WG Boege Fritz F Mielke Christian C
Cell cycle (Georgetown, Tex.) 20150101 11
To maintain genome stability, the thousands of replication origins of mammalian genomes must only initiate replication once per cell cycle. This is achieved by a strict temporal separation of ongoing replication in S phase, and the formation of pre-replicative complexes in the preceding G1 phase, which "licenses" each origin competent for replication. The contribution of the loading factor Cdc6 to the timing of the licensing process remained however elusive due to seemingly contradictory finding ...[more]