Targeting plasticity with vagus nerve stimulation to treat neurological disease.
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ABSTRACT:
SUBMITTER: Hays SA
PROVIDER: S-EPMC4615598 | biostudies-other | 2013
REPOSITORIES: biostudies-other
Publications
Targeting plasticity with vagus nerve stimulation to treat neurological disease.
Hays Seth A SA Rennaker Robert L RL Kilgard Michael P MP
Progress in brain research 20130101
Pathological neural activity in a variety of neurological disorders could be treated by directing plasticity to specifically renormalize aberrant neural circuits, thereby restoring normal function. Brief bursts of acetylcholine and norepinephrine can enhance the neural plasticity associated with coincident events. Vagus nerve stimulation (VNS) represents a safe and effective means to trigger the release of these neuromodulators with a high degree of temporal control. VNS-event pairing can genera ...[more]
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