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Structural and functional adaptations of the mammalian nuclear envelope to meet the meiotic requirements.

ABSTRACT: Numerous studies in the past years provided definite evidence that the nuclear envelope is much more than just a simple barrier. It rather constitutes a multifunctional platform combining structural and dynamic features to fulfill many fundamental functions such as chromatin organization, regulation of transcription, signaling, but also structural duties like maintaining general nuclear architecture and shape. One additional and, without doubt, highly impressive aspect is the recently identified key function of selected nuclear envelope components in driving meiotic chromosome dynamics, which in turn is essential for accurate recombination and segregation of the homologous chromosomes. Here, we summarize the recent work identifying new key players in meiotic telomere attachment and movement and discuss the latest advances in our understanding of the actual function of the meiotic nuclear envelope.

SUBMITTER: Link J

PROVIDER: S-EPMC4615672 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1.

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