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Mir-23a and mir-125b regulate neural stem/progenitor cell proliferation by targeting Musashi1.

ABSTRACT: Musashi1 is an RNA binding protein that controls the neural cell fate, being involved in maintaining neural progenitors in their proliferative state. In particular, its downregulation is needed for triggering early neural differentiation programs. In this study, we profiled microRNA expression during the transition from neural progenitors to differentiated astrocytes and underscored 2 upregulated microRNAs, miR-23a and miR-125b, that sinergically act to restrain Musashi1 expression, thus creating a regulatory module controlling neural progenitor proliferation.

SUBMITTER: Gioia U

PROVIDER: S-EPMC4615800 | biostudies-other | 2014

REPOSITORIES: biostudies-other

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Mir-23a and mir-125b regulate neural stem/progenitor cell proliferation by targeting Musashi1.

Gioia Ubaldo U Di Carlo Valerio V Caramanica Pasquale P Toselli Camilla C Cinquino Antonella A Marchioni Marcella M Laneve Pietro P Biagioni Stefano S Bozzoni Irene I Cacci Emanuele E Caffarelli Elisa E

RNA biology 20140101 9

Musashi1 is an RNA binding protein that controls the neural cell fate, being involved in maintaining neural progenitors in their proliferative state. In particular, its downregulation is needed for triggering early neural differentiation programs. In this study, we profiled microRNA expression during the transition from neural progenitors to differentiated astrocytes and underscored 2 upregulated microRNAs, miR-23a and miR-125b, that sinergically act to restrain Musashi1 expression, thus creatin ...[more]

PMID: 25483045

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