Ontology highlight
ABSTRACT:
SUBMITTER: Cabanski CR
PROVIDER: S-EPMC4615893 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Cabanski Christopher R CR White Nicole M NM Dang Ha X HX Silva-Fisher Jessica M JM Rauck Corinne E CE Cicka Danielle D Maher Christopher A CA
RNA biology 20150101 6
A growing number of gene-centric studies have highlighted the emerging significance of lncRNAs in cancer. However, these studies primarily focus on a single cancer type. Therefore, we conducted a pan-cancer analysis of lncRNAs comparing tumor and matched normal expression levels using RNA-Seq data from ∼ 3,000 patients in 8 solid tumor types. While the majority of differentially expressed lncRNAs display tissue-specific expression we discovered 229 lncRNAs with outlier or differential expression ...[more]