Ontology highlight
ABSTRACT:
SUBMITTER: Gamba G
PROVIDER: S-EPMC46173 | biostudies-other | 1993 Apr
REPOSITORIES: biostudies-other
Gamba G G Saltzberg S N SN Lombardi M M Miyanoshita A A Lytton J J Hediger M A MA Brenner B M BM Hebert S C SC
Proceedings of the National Academy of Sciences of the United States of America 19930401 7
Electroneutral Na+:Cl- cotransport systems are involved in a number of important physiological processes including salt absorption and secretion by epithelia and cell volume regulation. One group of Na+:Cl- cotransporters is specifically inhibited by the benzothiadiazine (thiazide) class of diuretic agents and can be distinguished from Na+:K+:2Cl- cotransporters based on a lack of K+ requirement and insensitivity to sulfamoylbenzoic acid diruetics like bumetanide. We report here the isolation of ...[more]