Ontology highlight
ABSTRACT:
SUBMITTER: Koldso H
PROVIDER: S-EPMC4618312 | biostudies-other | 2012 Dec
REPOSITORIES: biostudies-other
The journal of physical chemistry letters 20121115 23
Membrane proteins interact with their lipid bilayer environment via both a transmembrane helix and juxtamembrane regions. The effect of juxtamembrane regions and membrane lipid composition on these interactions has been explored by multiscale molecular dynamics simulations. The consequences of anionic lipids within the inner leaflet of a membrane were studied in combination with membrane spanning protein models differing in their juxtamembrane domains. The simulations reveal sensitivity of the p ...[more]