Ontology highlight
ABSTRACT:
SUBMITTER: Bowes C
PROVIDER: S-EPMC46215 | biostudies-other | 1993 Apr
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19930401 7
Retinal degeneration in the rd mouse is inherited as an autosomal recessive trait and is caused by a defect in the gene encoding the beta subunit of cGMP phosphodiesterase. Recently, a close genetic association of the rd gene with an endogenous xenotropic murine leukemia virus (Xmv-28) was established by linkage analysis using recombinant inbred strains of mice. In this study, genomic DNA mapping and sequence analyses clarify the position of the proviral sequences in relation to the rd gene. We ...[more]