Ontology highlight
ABSTRACT:
SUBMITTER: Chiasson-MacKenzie C
PROVIDER: S-EPMC4621825 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Chiasson-MacKenzie Christine C Morris Zachary S ZS Baca Quentin Q Morris Brett B Coker Joanna K JK Mirchev Rossen R Jensen Anne E AE Carey Thomas T Stott Shannon L SL Golan David E DE McClatchey Andrea I AI
The Journal of cell biology 20151019 2
The proliferation of normal cells is inhibited at confluence, but the molecular basis of this phenomenon, known as contact-dependent inhibition of proliferation, is unclear. We previously identified the neurofibromatosis type 2 (NF2) tumor suppressor Merlin as a critical mediator of contact-dependent inhibition of proliferation and specifically found that Merlin inhibits the internalization of, and signaling from, the epidermal growth factor receptor (EGFR) in response to cell contact. Merlin is ...[more]