Ontology highlight
ABSTRACT:
SUBMITTER: Ghamlouch H
PROVIDER: S-EPMC4621905 | biostudies-other | 2015 Jul
REPOSITORIES: biostudies-other
Ghamlouch Hussein H Darwiche Walaa W Hodroge Ahmed A Ouled-Haddou Hakim H Dupont Sébastien S Singh Amrathlal Rabbind AR Guignant Caroline C Trudel Stéphanie S Royer Bruno B Gubler Brigitte B Marolleau Jean-Pierre JP
Oncotarget 20150701 21
Recent research has shown that chronic lymphocytic leukemia (CLL) B-cells display a strong tendency to differentiate into antibody-secreting cells (ASCs) and thus may be amenable to differentiation therapy. However, the effect of this differentiation on factors associated with CLL pathogenesis has not been reported. In the present study, purified CLL B-cells were stimulated to differentiate into ASCs by phorbol myristate acetate or CpG oligodeoxynucleotide, in combination with CD40 ligand and cy ...[more]