The alpha aneurism: a structural motif revealed in an insertion mutant of staphylococcal nuclease.
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ABSTRACT:
SUBMITTER: Keefe LJ
PROVIDER: S-EPMC46282 | biostudies-other | 1993 Apr
REPOSITORIES: biostudies-other
Publications
The alpha aneurism: a structural motif revealed in an insertion mutant of staphylococcal nuclease.
Keefe L J LJ Sondek J J Shortle D D Lattman E E EE
Proceedings of the National Academy of Sciences of the United States of America 19930401 8
The x-ray crystal structure of a mutant of staphylococcal nuclease that contains a single glycine residue inserted in the C-terminal alpha-helix has been solved to 1.67 A resolution and refined to a crystallographic R value of 0.170. This inserted glycine residue is accommodated in the alpha-helix by formation of a previously uncharacterized bulge, which we term the alpha aneurism. A conformational search of known protein structures has identified the alpha aneurism in a number of protein famili ...[more]
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