Unknown

Dataset Information

0

The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance.


ABSTRACT: Adaptive immune responses depend on the capacity of T cells to target specific antigens. As similar antigens can be expressed by pathogens and host cells, the question naturally arises of how can T cells discriminate friends from foes. In this work, we suggest that T cells tolerate cells whose proliferation rates remain below a permitted threshold. Our proposal relies on well-established facts about T-cell dynamics during acute infections: T-cell populations are elastic (they expand and contract) and they display inertia (contraction is delayed relative to antigen removal). By modelling inertia and elasticity, we show that tolerance to slow-growing populations can emerge as a population-scale feature of T cells. This result suggests a theoretical framework to understand immune tolerance that goes beyond the self versus non-self dichotomy. It also accounts for currently unexplained observations, such as the paradoxical tolerance to slow-growing pathogens or the presence of self-reactive T cells in the organism.

SUBMITTER: Arias CF 

PROVIDER: S-EPMC4632576 | biostudies-other | 2015 Jul

REPOSITORIES: biostudies-other

altmetric image

Publications

The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance.

Arias Clemente F CF   Herrero Miguel A MA   Cuesta José A JA   Acosta Francisco J FJ   Fernández-Arias Cristina C  

Royal Society open science 20150708 7


Adaptive immune responses depend on the capacity of T cells to target specific antigens. As similar antigens can be expressed by pathogens and host cells, the question naturally arises of how can T cells discriminate friends from foes. In this work, we suggest that T cells tolerate cells whose proliferation rates remain below a permitted threshold. Our proposal relies on well-established facts about T-cell dynamics during acute infections: T-cell populations are elastic (they expand and contract  ...[more]

Similar Datasets

| S-EPMC1783362 | biostudies-literature
| S-EPMC3436737 | biostudies-literature
| S-EPMC8025685 | biostudies-literature
| S-EPMC2118488 | biostudies-other
| S-EPMC1681467 | biostudies-literature
| S-EPMC5634544 | biostudies-literature
| S-EPMC3585785 | biostudies-literature
| S-EPMC6588842 | biostudies-other
| S-EPMC3523072 | biostudies-literature
2022-12-27 | GSE221462 | GEO