Mutational Spectrum Analysis of Neurodegenerative Diseases and Its Pathogenic Implication.
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ABSTRACT:
SUBMITTER: Shen L
PROVIDER: S-EPMC4632750 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Publications
Mutational Spectrum Analysis of Neurodegenerative Diseases and Its Pathogenic Implication.
International journal of molecular sciences 20151014 10
One of the most conspicuous features of neurodegenerative diseases (NDs) is the occurrence of dramatic conformation change of individual proteins. We performed a mutational spectrum analysis of disease-causing missense mutations in seven types of NDs at nucleotide and amino acid levels, and compared the results with those of non-NDs. The main findings included: (i) The higher mutation ratio of G:C→T:A transversion to G:C→A:T transition was observed in NDs than in non-NDs, interpreting the excess ...[more]
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