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FluBlok, a recombinant hemagglutinin influenza vaccine.

ABSTRACT: FluBlok, a recombinant trivalent hemagglutinin (HA) vaccine produced in insect cell culture using the baculovirus expression system, provides an attractive alternative to the current egg-based trivalent inactivated influenza vaccine (TIV) manufacturing process. FluBlok contains three times more HA than TIV and does not contain egg-protein or preservatives. This review discusses the four main clinical studies that were used to support licensure of FluBlok under the 'Accelerated Approval' mechanism in the United States.

SUBMITTER: Cox MM 

PROVIDER: S-EPMC4634115 | biostudies-other | 2008 Nov

REPOSITORIES: biostudies-other

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FluBlok, a recombinant hemagglutinin influenza vaccine.

Cox Manon M J MM   Patriarca Peter A PA   Treanor John J  

Influenza and other respiratory viruses 20081101 6

FluBlok, a recombinant trivalent hemagglutinin (HA) vaccine produced in insect cell culture using the baculovirus expression system, provides an attractive alternative to the current egg-based trivalent inactivated influenza vaccine (TIV) manufacturing process. FluBlok contains three times more HA than TIV and does not contain egg-protein or preservatives. This review discusses the four main clinical studies that were used to support licensure of FluBlok under the 'Accelerated Approval' mechanis  ...[more]

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