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Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D.


ABSTRACT: Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented activated monocyte and anticancer T-cell tumor penetration and that anti-SEMA4D antibody potentiated other immunomodulatory therapies in murine tumor models.

SUBMITTER: Evans EE 

PROVIDER: S-EPMC4635900 | biostudies-other | 2015 Dec

REPOSITORIES: biostudies-other

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