Ontology highlight
ABSTRACT:
SUBMITTER: Nelson CR
PROVIDER: S-EPMC4639874 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
Nelson Christian R CR Hwang Tom T Chen Pin-Hsi PH Bhalla Needhi N
The Journal of cell biology 20151102 3
The spindle checkpoint acts during cell division to prevent aneuploidy, a hallmark of cancer. During checkpoint activation, Mad1 recruits Mad2 to kinetochores to generate a signal that delays anaphase onset. Yet, whether additional factors contribute to Mad2's kinetochore localization remains unclear. Here, we report that the conserved AAA+ ATPase TRIP13(PCH-2) localizes to unattached kinetochores and is required for spindle checkpoint activation in Caenorhabditis elegans. pch-2 mutants effectiv ...[more]