Ontology highlight
ABSTRACT:
SUBMITTER: Mendes P
PROVIDER: S-EPMC4642801 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
Mendes Pedro P Oliver Stephen G SG Kell Douglas B DB
Trends in pharmacological sciences 20151101 11
A recent paper in this journal argued that reported expression levels, kcat and Km for drug transporters could be used to estimate the likelihood that drug fluxes through Caco-2 cells could be accounted for solely by protein transporters. It was in fact concluded that if five such transporters contributed 'randomly' they could account for the flux of the most permeable drug tested (verapamil) 35% of the time. However, the values of permeability cited for verapamil were unusually high; this and o ...[more]