Ontology highlight
ABSTRACT:
SUBMITTER: Seetharamsingh B
PROVIDER: S-EPMC4645245 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
ACS medicinal chemistry letters 20151026 11
Therapeutic options for brain infections caused by pathogens with a reduced sensitivity to drugs are limited. Recent reports on the potential use of linezolid in treating brain infections prompted us to design novel compounds around this scaffold. Herein, we describe the design and synthesis of various oxazolidinone antibiotics with the incorporation of silicon. Our findings in preclinical species suggest that silicon incorporation is highly useful in improving brain exposures. Interestingly, th ...[more]