Ontology highlight
ABSTRACT:
SUBMITTER: Goh VJ
PROVIDER: S-EPMC4646211 | biostudies-other | 2015 Oct
REPOSITORIES: biostudies-other
Goh Vera J VJ Tan Jolene S Y JS Tan Bryan C BC Seow Colin C Ong Wei-Yi WY Lim Yen Ching YC Sun Lei L Ghosh Sujoy S Silver David L DL
The Journal of biological chemistry 20150824 42
Lipid droplets (LDs) are phylogenetically conserved cytoplasmic organelles that store neutral lipids within a phospholipid monolayer. LDs compartmentalize lipids and may help to prevent cellular damage caused by their excess or bioactive forms. FIT2 is a ubiquitously expressed transmembrane endoplasmic reticulum (ER) membrane protein that has previously been implicated in LD formation in mammalian cells and tissue. Recent data indicate that FIT2 plays an essential role in fat storage in an in vi ...[more]