Ontology highlight
ABSTRACT:
SUBMITTER: Choi I
PROVIDER: S-EPMC4647842 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
Choi Insup I Kim Beomsue B Byun Ji-Won JW Baik Sung Hoon SH Huh Yun Hyun YH Kim Jong-Hyeon JH Mook-Jung Inhee I Song Woo Keun WK Shin Joo-Ho JH Seo Hyemyung H Suh Young Ho YH Jou Ilo I Park Sang Myun SM Kang Ho Chul HC Joe Eun-Hye EH
Nature communications 20150914
In response to brain injury, microglia rapidly extend processes that isolate lesion sites and protect the brain from further injury. Here we report that microglia carrying a pathogenic mutation in the Parkinson's disease (PD)-associated gene, G2019S-LRRK2 (GS-Tg microglia), show retarded ADP-induced motility and delayed isolation of injury, compared with non-Tg microglia. Conversely, LRRK2 knockdown microglia are highly motile compared with control cells. In our functional assays, LRRK2 binds to ...[more]