Ontology highlight
ABSTRACT:
SUBMITTER: Marathe S
PROVIDER: S-EPMC4648324 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
Cell death and differentiation 20150327 11
Neurological disorders such as Alzheimer's disease, stroke and epilepsy are currently marred by the lack of effective treatments to prevent neuronal death. Erroneous cell cycle reentry (CCR) is hypothesized to have a causative role in neurodegeneration. We show that forcing S-phase reentry in cultured hippocampal neurons is sufficient to induce neurodegeneration. We found that kainic-acid treatment in vivo induces erroneous CCR and neuronal death through a Notch-dependent mechanism. Ablating Not ...[more]