Pre-diagnostic cruciferous vegetables intake and lung cancer survival among Chinese women.

ABSTRACT: No study to date has prospectively evaluated the association between pre-diagnostic cruciferous vegetables intake and lung cancer survival among women. This analysis included 547 incident lung cancer cases identified from the Shanghai Women's Health Study (SWHS) during the follow-up period of 1997-2011. Dietary intake was assessed for all SWHS participants at enrollment and reassessed 2-3 years later. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with adjustment for potential confounders. Of the 547 lung cancer patients, 412 patients died during the follow-up. A total of 393 (95.4%) deaths from lung cancer were documented with median survival time of 10.3 months (interquartile range, 3.6-21.1 months). High cruciferous vegetables intake was significantly associated with improved lung cancer-specific survival after adjusting for all nonclinical prognostic factors (n?=?547, HR?=?0.69; 95%CI?=?0.49-0.95; P trend?=?0.02) for the highest versus lowest quartile. A slightly stronger association of cruciferous vegetables intake with lung cancer-specific survival was observed in analyses restricted to patients with known clinical prognostic factors (n?=?331, HR?=?0.63; 95%CI?=?0.41-0.97; P trend?=?0.03) or never smokers (n?=?308, HR?=?0.58; 95%CI?=?0.37-0.91; P trend?=?0.02). In conclusion, pre-diagnostic cruciferous vegetables intake is associated with better survival of lung cancer in Chinese women.

SUBMITTER: Wu QJ 

PROVIDER: S-EPMC4650798 | biostudies-other | 2015 May

REPOSITORIES: biostudies-other