Ontology highlight
ABSTRACT:
SUBMITTER: Chuang R
PROVIDER: S-EPMC4650822 | biostudies-other | 2015 Feb
REPOSITORIES: biostudies-other
Scientific reports 20150203
Chronic Myeloid Leukemia (CML) represents a paradigm for the wider cancer field. Despite the fact that tyrosine kinase inhibitors have established targeted molecular therapy in CML, patients often face the risk of developing drug resistance, caused by mutations and/or activation of alternative cellular pathways. To optimize drug development, one needs to systematically test all possible combinations of drug targets within the genetic network that regulates the disease. The BioModelAnalyzer (BMA) ...[more]