Ontology highlight
ABSTRACT:
SUBMITTER: Ait Ouakrim D
PROVIDER: S-EPMC4651105 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
Ait Ouakrim Driss D Dashti Seyedeh Ghazaleh SG Chau Rowena R Buchanan Daniel D DD Clendenning Mark M Rosty Christophe C Winship Ingrid M IM Young Joanne P JP Giles Graham G GG Leggett Barbara B Macrae Finlay A FA Ahnen Dennis J DJ Casey Graham G Gallinger Steven S Haile Robert W RW Le Marchand Loïc L Thibodeau Stephen N SN Lindor Noralane M NM Newcomb Polly A PA Potter John D JD Baron John A JA Hopper John L JL Jenkins Mark A MA Win Aung Ko AK
Journal of the National Cancer Institute 20150624 9
<h4>Background</h4>Inheritance of a germline mutation in one of the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, and PMS2 causes a high risk of colorectal and other cancers (Lynch Syndrome). Use of aspirin has been shown to be associated with a reduced risk of colorectal cancer for the general population as well as for MMR gene mutation carriers. The aim of this study was to determine whether use of aspirin and ibuprofen in a nontrial setting is associated with the risk of colorectal cancer ...[more]