Treatment of amitriptyline intoxications by extended high cut-off dialysis.
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ABSTRACT:
SUBMITTER: Schmidt JJ
PROVIDER: S-EPMC4655799 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
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Treatment of amitriptyline intoxications by extended high cut-off dialysis.
Schmidt Julius J JJ Bertram Anna A Kühn-Velten W Nikolaus WN Suhling Hendrik H Wiesner Olaf O Schneider Andrea A Kielstein Jan T JT
Clinical kidney journal 20150929 6
Antidepressants, especially amitriptyline, are among the most frequent drug classes involved in intoxications. Despite its small molecular weight, amitriptyline is not considered to be eliminated by extracorporeal treatment methods due to its high protein binding and large volume of distribution. New high cut-off dialysers have so far not been used for removal of amitriptyline. We report two cases of amitriptyline poisoning in which we measured the amitriptyline elimination using extended high c ...[more]
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