Ontology highlight
ABSTRACT:
SUBMITTER: Saveljeva S
PROVIDER: S-EPMC4669746 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Saveljeva S S Mc Laughlin S L SL Vandenabeele P P Samali A A Bertrand M J M MJ
Cell death & disease 20150108
Endoplasmic reticulum (ER) stress-induced cellular dysfunction and death is associated with several human diseases. It has been widely reported that ER stress kills through activation of the intrinsic mitochondrial apoptotic pathway. Here we demonstrate that ER stress can also induce necroptosis, an receptor-interacting protein kinase 1 (RIPK1)/RIPK3/mixed lineage kinase domain-like protein (MLKL)-dependent form of necrosis. Remarkably, we observed that necroptosis induced by various ER stressor ...[more]