Ontology highlight
ABSTRACT:
SUBMITTER: Shklover J
PROVIDER: S-EPMC4669801 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Shklover J J Mishnaevski K K Levy-Adam F F Kurant E E
Cell death & disease 20150219
Glial phagocytosis of superfluous neurons and damaged or aberrant neuronal material is crucial for normal development and maintenance of the CNS. However, the molecular mechanisms underlying the relationship between neuronal death and glial phagocytosis are poorly understood. We describe a novel mechanism that is able to synchronize neuronal cell death and glial phagocytosis of dying neurons in the Drosophila embryonic CNS. This mechanism involves c-Jun N-terminal kinase (JNK) signaling, which i ...[more]