Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation.
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ABSTRACT:
SUBMITTER: Touvier T
PROVIDER: S-EPMC4669802 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Publications
Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation.
Touvier T T De Palma C C Rigamonti E E Scagliola A A Incerti E E Mazelin L L Thomas J-L JL D'Antonio M M Politi L L Schaeffer L L Clementi E E Brunelli S S
Cell death & disease 20150226
Mitochondrial fission and fusion are essential processes in the maintenance of the skeletal muscle function. The contribution of these processes to muscle development has not been properly investigated in vivo because of the early lethality of the models generated so far. To define the role of mitochondrial fission in muscle development and repair, we have generated a transgenic mouse line that overexpresses the fission-inducing protein Drp1 specifically in skeletal muscle. These mice displayed ...[more]
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