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Cracking the code of neuronal apoptosis and survival.


ABSTRACT: Neuronal apoptosis and survival are tightly controlled processes that regulate cell fate during the development of the central nervous system and its homeostasis throughout adulthood. A new study in primary cultures of cerebellar granule neurons identified common transcriptional cascades during rescue from apoptosis by insulin-like growth factor-1 (Igf1) and pituitary adenylyl cyclase-activating polypeptide (Pacap), thus suggesting the existence of a high degree of conservation of cell survival pathways.

SUBMITTER: Cavallaro S 

PROVIDER: S-EPMC4670922 | biostudies-other | 2015

REPOSITORIES: biostudies-other

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