Ontology highlight
ABSTRACT:
SUBMITTER: Kotsampasakou E
PROVIDER: S-EPMC4674819 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Kotsampasakou Eleni E Brenner Stefan S Jäger Walter W Ecker Gerhard F GF
Molecular pharmaceutics 20151102 12
Organic anion transporting polypeptides 1B1 and 1B3 are transporters selectively expressed on the basolateral membrane of the hepatocyte. Several studies reveal that they are involved in drug-drug interactions, cancer, and hyperbilirubinemia. In this study, we developed a set of classification models for OATP1B1 and 1B3 inhibition based on more than 1700 carefully curated compounds from literature, which were validated via cross-validation and by use of an external test set. After combining seve ...[more]