One node driving synchronisation.
Ontology highlight
ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC4676025 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Similar Datasets
Project description:We investigate a no-boarding policy in a system of N buses serving M bus stops in a loop, which is an entrainment mechanism to keep buses synchronised in a reasonably staggered configuration. Buses always allow alighting, but would disallow boarding if certain criteria are met. For an analytically tractable theory, buses move with the same natural speed (applicable to programmable self-driving buses), where the average waiting time experienced by passengers waiting at the bus stop for a bus to arrive can be calculated. The analytical results show that a no-boarding policy can dramatically reduce the average waiting time, as compared to the usual situation without the no-boarding policy. Subsequently, we carry out simulations to verify these theoretical analyses, also extending the simulations to typical human-driven buses with different natural speeds based on real data. Finally, a simple general adaptive algorithm is implemented to dynamically determine when to implement no-boarding in a simulation for a real university shuttle bus service.
| S-EPMC7089533 | biostudies-literature
Project description:Bus bunching is a perennial phenomenon that not only diminishes the efficiency of a bus system, but also prevents transit authorities from keeping buses on schedule. We present a physical theory of buses serving a loop of bus stops as a ring of coupled self-oscillators, analogous to the Kuramoto model. Sustained bunching is a repercussion of the process of phase synchronisation whereby the phases of the oscillators are locked to each other. This emerges when demand exceeds a critical threshold. Buses also bunch at low demand, albeit temporarily, due to frequency detuning arising from different human drivers' distinct natural speeds. We calculate the critical transition when complete phase locking (full synchronisation) occurs for the bus system, and posit the critical transition to completely no phase locking (zero synchronisation). The intermediate regime is the phase where clusters of partially phase locked buses exist. Intriguingly, these theoretical results are in close correspondence to real buses in a university's shuttle bus system.
| S-EPMC6499774 | biostudies-literature
Project description:Biliary tract cancer ranks among the most lethal human malignancies, representing an unmet clinical need. Its abysmal prognosis is tied to an increasing incidence and a fundamental lack of mechanistic knowledge regarding the molecular basis of the disease. Here, we show that the Pdx1-positive extrahepatic biliary epithelium is highly susceptible toward transformation by activated PIK3CAH1047R but refractory to oncogenic KrasG12D. Using genome-wide transposon screens and genetic loss-of-function experiments, we discover context-dependent genetic interactions that drive extrahepatic cholangiocarcinoma (ECC) and show that PI3K signaling output strength and repression of the tumor suppressor p27Kip1 are critical context-specific determinants of tumor formation. This contrasts with the pancreas, where oncogenic Kras in concert with p53 loss is a key cancer driver. Notably, inactivation of p27Kip1 permits KrasG12D-driven ECC development. These studies provide a mechanistic link between PI3K signaling, tissue-specific tumor suppressor barriers, and ECC pathogenesis, and present a novel genetic model of autochthonous ECC and genes driving this highly lethal tumor subtype.SignificanceWe used the first genetically engineered mouse model for extrahepatic bile duct carcinoma to identify cancer genes by genome-wide transposon-based mutagenesis screening. Thereby, we show that PI3K signaling output strength and p27Kip1 function are critical determinants for context-specific ECC formation. This article is highlighted in the In This Issue feature, p. 2945.
| S-EPMC7612573 | biostudies-literature
Project description:Acting in synchrony is a fundamental part of many social interactions and can have pro-social consequences. Explanations for this relationship were investigated here using implicit measures of imitation (automatic imitation task) and memory (preference overlap task). In Study 1, participants performed an intentional synchronisation task where they moved sliders in or out of time with another person while a third person observed. Those who had moved in synchrony showed a stronger tendency to imitate their partner's actions than those who had moved in a non-synchronous way. Similarly, coordinated partners were also more likely to share object preferences. Results also showed that rather than memory blurring between co-actors, participants had improved memories for the self. Study 2 exchanged intentional for incidental coordination (coordinating with a synchronous metronome). None of the findings from Study 1 replicated when synchronisation was incidental rather than intentional, suggesting that having a shared goal may be critical for triggering effects of synchronisation on imitation tendencies and memory. Together these findings favour explanations related to changes in social categorisation over representational overlap between co-actors.
| S-EPMC7804244 | biostudies-literature
Project description:Background: Cardiac pacemaking remains an unsolved matter from many perspectives. Extensive experimental and computational studies have been performed to describe the sinoatrial physiology across different scales, from the molecular to clinical levels. Nevertheless, the mechanism by which a heartbeat is generated inside the sinoatrial node and propagated to the working myocardium is not fully understood at present. This work aims to provide quantitative information about this fascinating phenomenon, especially regarding the contributions of cellular heterogeneity and fibroblasts to sinoatrial node automaticity and atrial driving. Methods: We developed a bidimensional computational model of the human right atrial tissue, including the sinoatrial node. State-of-the-art knowledge of the anatomical and physiological aspects was adopted during the design of the baseline tissue model. The novelty of this study is the consideration of cellular heterogeneity and fibroblasts inside the sinoatrial node for investigating the manner by which they tune the robustness of stimulus formation and conduction under different conditions (baseline, ionic current blocks, autonomic modulation, and external high-frequency pacing). Results: The simulations show that both heterogeneity and fibroblasts significantly increase the safety factor for conduction by more than 10% in almost all the conditions tested and shorten the sinus node recovery time after overdrive suppression by up to 60%. In the human model, especially under challenging conditions, the fibroblasts help the heterogeneous myocytes to synchronise their rate (e.g. -82% in σCL under 25 nM of acetylcholine administration) and capture the atrium (with 25% L-type calcium current block). However, the anatomical and gap junctional coupling aspects remain the most important model parameters that allow effective atrial excitations. Conclusion: Despite the limitations to the proposed model, this work suggests a quantitative explanation to the astonishing overall heterogeneity shown by the sinoatrial node.
| S-EPMC11319284 | biostudies-literature
Project description:The pedestrian-induced instability of the London Millennium Bridge is a widely used example of Kuramoto synchronisation. Yet, reviewing observational, experimental, and modelling evidence, we argue that increased coherence of pedestrians' foot placement is a consequence of, not a cause of the instability. Instead, uncorrelated pedestrians produce positive feedback, through negative damping on average, that can initiate significant lateral bridge vibration over a wide range of natural frequencies. We present a simple general formula that quantifies this effect, and illustrate it through simulation of three mathematical models, including one with strong propensity for synchronisation. Despite subtle effects of gait strategies in determining precise instability thresholds, our results show that average negative damping is always the trigger. More broadly, we describe an alternative to Kuramoto theory for emergence of coherent oscillations in nature; collective contributions from incoherent agents need not cancel, but can provide positive feedback on average, leading to global limit-cycle motion.
| S-EPMC8664840 | biostudies-literature
Project description:To maintain synchrony in group activities, each individual within the group must continuously correct their movements to remain in time with the temporal cues available. Cues might originate from one or more members of the group. Current research suggests that when synchronising movements, individuals optimise their performance in terms of minimising variability of timing errors (asynchronies) between external cues and their own movements. However, the cost of this is an increase in the timing variability of their own movements. Here we investigate whether an individual's timing strategy changes according to the task, in a group scenario. To investigate this, we employed a novel paradigm that positioned six individuals to form two chains with common origin and termination on the circumference of a circle. We found that participants with access to timing cues from only one other member used a strategy to minimise their asynchrony variance. In contrast, the participant at the common termination of the two chains, who was required to integrate timing cues from two members, used a strategy that minimised movement variability. We conclude that humans are able to flexibly switch timekeeping strategies to maintain task demands and thus optimise the temporal performance of their movements.
| S-EPMC4726081 | biostudies-literature
Project description:The transition between synchronized and asynchronous behaviour of immobilized yeast cells of the strain Saccharomyces carlsbergensis was investigated by monitoring the autofluorescence of the coenzyme NADH. In populations of intermediate cell densities the individual cells remained oscillatory, whereas on the level of the cell population both a partially synchronized and an asynchronous state were accessible for experimental studies. In the partially synchronized state, the mean oscillatory frequency was larger than that of the cells in the asynchronous state. This suggests that synchronisation occurred due to entrainment by the cells that oscillated more rapidly. This is typical for synchronisation due to phase advancement. Furthermore, the synchronisation of the frequency of the glycolytic oscillations preceded the synchronisation of their phases. However, the cells did not synchronize completely, as the distribution of the oscillatory frequencies only narrowed but did not collapse to a unique frequency. Cells belonging to spatially denser clusters showed a slightly enhanced local synchronisation during the episode of partial synchronisation. Neither the clusters nor a transition from partially synchronized glycolytic oscillations to travelling glycolytic waves did substantially affect the degree of partial synchronisation. Chimera states, i.e., the coexistence of a synchronized and an asynchronous part of the population, could not be found.
| S-EPMC7661732 | biostudies-literature
Project description:Being able to produce sounds that capture attention and elicit rapid reactions is the prime goal of communication. One strategy, exploited by alarm signals, consists in emitting fast but perceptible amplitude modulations in the roughness range (30-150 Hz). Here, we investigate the perceptual and neural mechanisms underlying aversion to such temporally salient sounds. By measuring subjective aversion to repetitive acoustic transients, we identify a nonlinear pattern of aversion restricted to the roughness range. Using human intracranial recordings, we show that rough sounds do not merely affect local auditory processes but instead synchronise large-scale, supramodal, salience-related networks in a steady-state, sustained manner. Rough sounds synchronise activity throughout superior temporal regions, subcortical and cortical limbic areas, and the frontal cortex, a network classically involved in aversion processing. This pattern correlates with subjective aversion in all these regions, consistent with the hypothesis that roughness enhances auditory aversion through spreading of neural synchronisation.
| S-EPMC6694125 | biostudies-literature
Project description: Not available
| S-EPMC10641163 | biostudies-literature