Ontology highlight
ABSTRACT:
SUBMITTER: Johnson JD
PROVIDER: S-EPMC46784 | biostudies-other | 1993 Jun
REPOSITORIES: biostudies-other
Johnson J D JD Edman J C JC Rutter W J WJ
Proceedings of the National Academy of Sciences of the United States of America 19930601 12
We have identified a breast carcinoma tyrosine phosphoprotein, discoidin domain receptor (DDR), that defines an unusual class of receptor tyrosine kinases. The DDR cDNA predicts a C-terminal tyrosine kinase domain and an N-terminal domain similar to the Dictyostelium discoideum lectin discoidin I. These domains are connected by an extraordinary hydrophilic proline/glycine-rich domain, which is interrupted by a predicted transmembrane sequence. This extended proline/glycine-rich region may be req ...[more]