Ontology highlight
ABSTRACT:
SUBMITTER: Jauker M
PROVIDER: S-EPMC4678514 | biostudies-other | 2015 Nov
REPOSITORIES: biostudies-other
Angewandte Chemie (International ed. in English) 20151005 48
Template-directed incorporation of nucleotides at the terminus of a growing complementary strand is the basis of replication. For RNA, this process can occur in the absence of enzymes, if the ribonucleotides are first converted to an active species with a leaving group. Thus far, the activation required a separate chemical step, complicating prebiotically plausible scenarios. Here we show that a combination of a carbodiimide and an organocatalyst induces near-quantitative incorporation of any of ...[more]