Ontology highlight
ABSTRACT:
SUBMITTER: Cho SJ
PROVIDER: S-EPMC4682089 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Stem cell reports 20151112 6
Stem-toxic small molecules have been developed to induce selective cell death of pluripotent stem cells (PSCs) to lower the risk of teratoma formation. However, despite their high efficacies, chemical-based approaches may carry unexpected toxicities on specific differentiated cell types. Herein, we took advantage of KillerRed (KR) as a suicide gene, to selectively induce phototoxicity using visible light via the production of reactive oxygen species. PSCs in an undifferentiated state that exclus ...[more]