Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study.
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ABSTRACT:
SUBMITTER: Noli L
PROVIDER: S-EPMC4682124 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Publications
Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study.
Noli Laila L Capalbo Antonio A Ogilvie Caroline C Khalaf Yacoub Y Ilic Dusko D
Stem cell reports 20151112 6
Discordant growth is a common complication of monochorionic/diamniotic pregnancies; in approximately 50% of cases, the cause is unknown. The case presented here suggests that discordant growth of monozygotic twins could start during preimplantation development. Two inner cell masses (ICMs) within the same blastocyst may originate in uneven splitting of a single "parental" ICM, or the two ICMs may be formed independently de novo. We studied the transcriptomes of two morphologically distinct ICMs ...[more]
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