Ontology highlight
ABSTRACT:
SUBMITTER: Ricchi P
PROVIDER: S-EPMC4687615 | biostudies-other | 2015
REPOSITORIES: biostudies-other
Drug design, development and therapy 20151216
It has been clearly shown that iron overload adds progressively significant morbidity and mortality in patients with non-transfusion-dependent thalassemia (NTDT). The lack of physiological mechanisms to eliminate the excess of iron requires effective iron chelation therapy. The reduced compliance to deferoxamine and the risk of severe hematological adverse events during deferiprone treatment have limited the use of both these drugs to correct iron imbalance in NTDT. According to the principles o ...[more]