Unknown

Dataset Information

0

Meta-analysis of association of the matrix metalloproteinase 2 (-735 C/T) polymorphism with cancer risk.


ABSTRACT: The association between matrix metalloproteinase 2 (MMP2) gene polymorphisms and cancer risk has been investigated in many published studies; however, the currently available results are inconclusive. Therefore, we performed a meta-analysis to provide conclusive evidence for an association between the MMP2 polymorphism (-735 C/T) and cancer risk. Sixteen case-control studies with 11792 individuals were included in this meta-analysis. The odds ratio (OR) and 95% confidence interval (95% CI) were used to investigate the strength of the association. Overall, the MMP2 polymorphism (-735 C/T) was not associated with cancer risk in any of the models. However, the subgroup analysis revealed that dominant model (C/T+T/T vs. C/C: OR=1.24, 95% CI=1.01-1.53) and codominant 1 model (C/T vs. C/C: OR=1.30, 95% CI=1.05-1.62) were significantly associated with cancer risk in the Caucasian population. In conclusion, our meta-analysis indicated that the MMP2 polymorphism (-735 C/T) might be genetic risk factor for the carcinogenesis in Caucasians. However, more studies with a larger sample size are needed to provide more precise evidence.

SUBMITTER: Kim SK 

PROVIDER: S-EPMC4694202 | biostudies-other | 2015

REPOSITORIES: biostudies-other

altmetric image

Publications

Meta-analysis of association of the matrix metalloproteinase 2 (-735 C/T) polymorphism with cancer risk.

Kim Su Kang SK   Kang Sang Wook SW   Park Hae Jeong HJ   Ban Ju Yeon JY   Oh Chung-Hun CH   Chung Joo-Ho JH   Oh In-Hwan IH   Cho Kyu Bong KB   Park Min-Su MS  

International journal of clinical and experimental medicine 20151015 10


The association between matrix metalloproteinase 2 (MMP2) gene polymorphisms and cancer risk has been investigated in many published studies; however, the currently available results are inconclusive. Therefore, we performed a meta-analysis to provide conclusive evidence for an association between the MMP2 polymorphism (-735 C/T) and cancer risk. Sixteen case-control studies with 11792 individuals were included in this meta-analysis. The odds ratio (OR) and 95% confidence interval (95% CI) were  ...[more]

Similar Datasets

| S-EPMC3906197 | biostudies-literature
| S-EPMC6223342 | biostudies-literature
| S-EPMC3610819 | biostudies-literature
| S-EPMC4483846 | biostudies-literature
| S-EPMC6465197 | biostudies-literature
| S-EPMC6410464 | biostudies-literature
| S-EPMC4247749 | biostudies-literature
| S-EPMC4461879 | biostudies-literature
| S-EPMC5823656 | biostudies-literature
| S-EPMC3596673 | biostudies-other