Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition.
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ABSTRACT:
SUBMITTER: Zhu X
PROVIDER: S-EPMC4694834 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
Publications
Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition.
Zhu Xiaoping X Zhong Jing J Zhao Zhen Z Sheng Jianting J Wang Jiang J Liu Jiyong J Cui Kemi K Chang Jenny J Zhao Hong H Wong Stephen S
Oncotarget 20150901 28
Interactions among tumor cells, stromal cells, and extracellular matrix compositions are mediated through cytokines during tumor progression. Our analysis of 132 known cytokines and growth factors in published clinical breast cohorts and our 84 patient-derived xenograft models revealed that the elevated connective tissue growth factor (CTGF) in tumor epithelial cells significantly correlated with poor clinical prognosis and outcomes. CTGF was able to induce tumor cell epithelial-mesenchymal tran ...[more]
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