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MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer.

ABSTRACT: Growing evidence indicates that microRNA (miRNA) plays a vital role in progression and metastasis of gastric cancer (GC). However, the underlying mechanism of miRNA-mediated metastasis has not been fully understood. Recently, miRNA-940 (miR-940) was found to be overexpressed in GC, which correlated with malignant progression and poor survival. Mechanistically, we found that miR-940 promoted GC cell migration, invasion, and metastasis in vivo by directly and functionally repressing the expression of Zinc Finger Transcription Factor 24 (ZNF24). Importantly, upregulation of ZNF24 could re-inhibit miR-940-induced migration and invasion. Hence, we demonstrated the oncogenic role of miR-940 in GC, finding that miR-940 promoted GC progression by directly downregulating ZNF24 expression, and targeting miR-940 could serve as a novel strategy for future GC therapy.

SUBMITTER: Liu X

PROVIDER: S-EPMC4694841 | biostudies-other | 2015 Sep

REPOSITORIES: biostudies-other

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MicroRNA-940 promotes tumor cell invasion and metastasis by downregulating ZNF24 in gastric cancer.

Liu Xinyang X Ge Xiaoxiao X Zhang Zhe Z Zhang Xiaowei X Chang Jinjia J Wu Zheng Z Tang Wenbo W Gan Lu L Sun Menghong M Li Jin J

Oncotarget 20150901 28

Growing evidence indicates that microRNA (miRNA) plays a vital role in progression and metastasis of gastric cancer (GC). However, the underlying mechanism of miRNA-mediated metastasis has not been fully understood. Recently, miRNA-940 (miR-940) was found to be overexpressed in GC, which correlated with malignant progression and poor survival. Mechanistically, we found that miR-940 promoted GC cell migration, invasion, and metastasis in vivo by directly and functionally repressing the expression ...[more]

PMID: 26317898

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