Ontology highlight
ABSTRACT:
SUBMITTER: Scholz SL
PROVIDER: S-EPMC4694872 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
Scholz Simone L SL Horn Susanne S Murali Rajmohan R Möller Inga I Sucker Antje A Sondermann Wiebke W Stiller Mathias M Schilling Bastian B Livingstone Elisabeth E Zimmer Lisa L Reis Henning H Metz Claudia H CH Zeschnigk Michael M Paschen Annette A Steuhl Klaus-Peter KP Schadendorf Dirk D Westekemper Henrike H Griewank Klaus G KG
Oncotarget 20150901 28
<h4>Objectives</h4>Recently, recurrent mutations in regulatory DNA regions, such as promoter mutations in the TERT gene were identified in melanoma. Subsequently, Weinhold et al. reported SDHD promoter mutations occurring in 10% of melanomas and being associated with a lower overall survival rate. Our study analyzes the mutation rate and clinico-pathologic associations of SDHD promoter mutations in a large cohort of different melanoma subtypes.<h4>Methods</h4>451 melanoma samples (incl. 223 non- ...[more]