CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination.
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ABSTRACT:
SUBMITTER: Ravindranath AK
PROVIDER: S-EPMC4694903 | biostudies-other | 2015 Sep
REPOSITORIES: biostudies-other
Publications
CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination.
Ravindranath Abhilash K AK Kaur Swayamjot S Wernyj Roman P RP Kumaran Muthu N MN Miletti-Gonzalez Karl E KE Chan Rigel R Lim Elaine E Madura Kiran K Rodriguez-Rodriguez Lorna L
Oncotarget 20150901 28
Here we demonstrate that a ubiquitin E3-ligase, FBXO21, targets the multidrug resistance transporter, ABCB1, also known as P-glycoprotein (P-gp), for proteasomal degradation. We also show that the Ser291-phosphorylated form of the multifunctional protein and stem cell marker, CD44, inhibits FBXO21-directed degradation of P-gp. Thus, CD44 increases P-gp mediated drug resistance and represents a potential therapeutic target in P-gp-positive cells. ...[more]
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