Ontology highlight
ABSTRACT:
SUBMITTER: Monteclaro FS
PROVIDER: S-EPMC47005 | biostudies-other | 1993 Jul
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 19930701 14
A lambda gt11 cDNA library of chicken embryo fibroblasts was screened with biotinylated Jun protein to identify Jun-binding clones. Eight such clones were isolated; one contains a gene referred to as jif-1 that is homologous to the putative tumor suppressor gene QM. jif-1 codes for a protein of 25 kDa that binds to the leucine zipper of viral and cellular Jun. The Jif-1 protein also binds to itself. Jif-1 does not contain a leucine zipper, and it does not bind to the 12-O-tetradecanoylphorbol 13 ...[more]