Ontology highlight
ABSTRACT:
SUBMITTER: Friedman J
PROVIDER: S-EPMC47023 | biostudies-other | 1993 Jul
REPOSITORIES: biostudies-other
Friedman J J Trahey M M Weissman I I
Proceedings of the National Academy of Sciences of the United States of America 19930701 14
We report the protein purification and the cloning and characterization of a cDNA encoding the proteins that bind with high affinity to cyclophilin C (Cyp-C) in the absence of cyclosporin A. Transfection of this cDNA into COS cells directs the production of a glycoprotein of 77 kDa that binds to Cyp-C in the absence, but not the presence, of cyclosporin A. Homology comparisons reveal that this protein and gene, termed CyCAP for Cyp-C-associated protein, possess a cysteine-rich domain (scavenger ...[more]