Ontology highlight
ABSTRACT:
SUBMITTER: Raab S
PROVIDER: S-EPMC4703809 | biostudies-other | 2016 Jan
REPOSITORIES: biostudies-other
Raab Susanne S Wang Haiyan H Uhles Sabine S Cole Nadine N Alvarez-Sanchez Ruben R Künnecke Basil B Ullmer Christoph C Matile Hugues H Bedoucha Marc M Norcross Roger D RD Ottaway-Parker Nickki N Perez-Tilve Diego D Conde Knape Karin K Tschöp Matthias H MH Hoener Marius C MC Sewing Sabine S
Molecular metabolism 20151101 1
<h4>Objective</h4>Type 2 diabetes and obesity are emerging pandemics in the 21st century creating worldwide urgency for the development of novel and safe therapies. We investigated trace amine-associated receptor 1 (TAAR1) as a novel target contributing to the control of glucose homeostasis and body weight.<h4>Methods</h4>We investigated the peripheral human tissue distribution of TAAR1 by immunohistochemistry and tested the effect of a small molecule TAAR1 agonist on insulin secretion in vitro ...[more]