Ontology highlight
ABSTRACT:
SUBMITTER: Labro AJ
PROVIDER: S-EPMC4703866 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Labro Alain J AJ Priest Michael F MF Lacroix Jérôme J JJ Snyders Dirk J DJ Bezanilla Francisco F
Nature communications 20151217
High-frequency action potential (AP) transmission is essential for rapid information processing in the central nervous system. Voltage-dependent Kv3 channels play an important role in this process thanks to their high activation threshold and fast closure kinetics, which reduce the neuron's refractory period. However, premature Kv3 channel closure leads to incomplete membrane repolarization, preventing sustainable AP propagation. Here, we demonstrate that Kv3.1b channels solve this problem by pr ...[more]