Ontology highlight
ABSTRACT:
SUBMITTER: Jozwik A
PROVIDER: S-EPMC4703893 | biostudies-other | 2015 Dec
REPOSITORIES: biostudies-other
Jozwik Agnieszka A Habibi Maximillian S MS Paras Allan A Zhu Jie J Guvenel Aleks A Dhariwal Jaideep J Almond Mark M Wong Ernie H C EHC Sykes Annemarie A Maybeno Matthew M Del Rosario Jerico J Trujillo-Torralbo Maria-Belen MB Mallia Patrick P Sidney John J Peters Bjoern B Kon Onn Min OM Sette Alessandro A Johnston Sebastian L SL Openshaw Peter J PJ Chiu Christopher C
Nature communications 20151221
In animal models, resident memory CD8+ T (Trm) cells assist in respiratory virus elimination but their importance in man has not been determined. Here, using experimental human respiratory syncytial virus (RSV) infection, we investigate systemic and local virus-specific CD8+ T-cell responses in adult volunteers. Having defined the immunodominance hierarchy, we analyse phenotype and function longitudinally in blood and by serial bronchoscopy. Despite rapid clinical recovery, we note surprisingly ...[more]