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Reduced risk of prostate cancer in childless men as compared to fathers: a systematic review and meta-analysis.


ABSTRACT: The previously reported association between fatherhood status and prostate cancer risk was controversial. We carried out the present meta-analysis of all relevant studies to summarize evidence on this association. A comprehensive literature search of studies was performed in PubMed, Web of Science, and the Chinese National Knowledge Infrastructure (CNKI) databases, covering all the papers published from their inception to September 2015. The combined risk estimates with 95% confidence intervals (CIs) were calculated using a random effects model. Heterogeneity and publication bias were also evaluated. A total of 11 studies were finally included in this meta-analysis. We found a significantly reduced risk of prostate cancer associated with being childless (OR 0.91, 95% CI 0.87-0.96). There was statistically significant heterogeneity across the studies (P?

SUBMITTER: Mao Y 

PROVIDER: S-EPMC4707492 | biostudies-other | 2016 Jan

REPOSITORIES: biostudies-other

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Reduced risk of prostate cancer in childless men as compared to fathers: a systematic review and meta-analysis.

Mao Yeqing Y   Xu Xin X   Zheng Xiangyi X   Xie Liping L  

Scientific reports 20160111


The previously reported association between fatherhood status and prostate cancer risk was controversial. We carried out the present meta-analysis of all relevant studies to summarize evidence on this association. A comprehensive literature search of studies was performed in PubMed, Web of Science, and the Chinese National Knowledge Infrastructure (CNKI) databases, covering all the papers published from their inception to September 2015. The combined risk estimates with 95% confidence intervals  ...[more]

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