Ontology highlight
ABSTRACT:
SUBMITTER: Koenitzer JR
PROVIDER: S-EPMC4710799 | biostudies-other | 2016 Aug
REPOSITORIES: biostudies-other
Koenitzer Jeffrey R JR Bonacci Gustavo G Woodcock Steven R SR Chen Chen-Shan CS Cantu-Medellin Nadiezhda N Kelley Eric E EE Schopfer Francisco J FJ
Redox biology 20151117
Nitro-fatty acids (NO2-FA) are metabolic and inflammatory-derived electrophiles that mediate pleiotropic signaling actions. It was hypothesized that NO2-FA would impact mitochondrial redox reactions to induce tissue-protective metabolic shifts in cells. Nitro-oleic acid (OA-NO2) reversibly inhibited complex II-linked respiration in isolated rat heart mitochondria in a pH-dependent manner and suppressed superoxide formation. Nitroalkylation of Fp subunit was determined by BME capture and the site ...[more]